双边性,而不是多焦点性,是低风险乳头甲状腺癌复发的独立风险因素
Pedro Manuel Rodriguez Schaap1, Jia Feng Lin2, Madelon J H Metman2
1Department of Surgery, Amsterdam University Medical Centres, location VUmc, Cancer Center Amsterdam, Amsterdam, the Netherlands.
Journal of the National Cancer Institute
|June 2, 2023
概括
对于低风险的乳头甲状腺癌 (PTC),双边性是复发的重要预测因素. 这一发现对于定制像甲状腺切除术这样的缓解升级治疗策略至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 手术病理学手术病理学
背景情况:
- 乳头甲状腺癌 (PTC) 复发风险受到多焦点性和双边性的影响.
- 对于低风险的PTC,应考虑降级治疗策略 (甲状腺切除术).
- 了解逆侧瘤的概率是治疗决策的关键.
研究的目的:
- 分析低风险PTC患者的逆侧瘤概率.
- 评估多焦点性和双边性作为复发的预测因素.
- 为了告知低风险PTC的降级治疗策略.
主要方法:
- 对791名低风险PTC患者 (2005-2015) 的回顾性研究.
- 数据来源于荷兰综合癌症组织 (IKNL) 和PALGA.
- 评估相反的瘤概率和复发率.
主要成果:
- 41.8%的患者患有多焦点疾病;68.9%的人患有双边疾病.
- 对侧面瘤的概率为单焦性疾病的24.6%,多焦性疾病的43.1%.
- 双边性 (HR=3.621) 是复发的唯一显著预测因素.
结论:
- 在多焦点或双边低风险PTC中观察到较低的复发率.
- 双边性是缓解治疗考虑的关键因素.
- 进一步的研究可能会完善PTC管理的风险分层.
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