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使用NIH工具箱评估临床显著的认知障碍,用于同时出现严重精神疾病和酒精使用障碍的个人
Julianne D Jett1, Gordon Kordas, Sara Parent
1From the Department of Community and Behavioral Health, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA (JDJ, GK, SP, MK, RS, PK, SMM, JMR, MGM, NC); and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA (RR).
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概括
在患有严重精神疾病和酒精使用障碍的人群中,认知障碍很普遍. 较高的酒精使用障碍严重程度,负面精神症状和头部损伤史与这种障碍有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 成 药物 药物 药物 药物
背景情况:
- 严重精神疾病 (SMI) 和酒精使用障碍 (AUD) 的同时发生很常见.
- 对于SMI和AUD (SMI-AUD) 同时发生的个体的认知障碍的了解有限.
研究的目的:
- 在SMI-AUD.患者中确定临床显著的认知障碍 (CSCI).
- 描述这一群体的认知特征.
- 调查与CSCI相关的风险因素,包括精神病和AUD严重程度.
主要方法:
- 利用NIH工具箱进行认知评估.
- 基于特定的子测试得分值相对于结晶能力而定义的CSCI.
- 使用SCID-5和PANSS评估精神病的严重程度.
- 通过SCID-5测量AUD严重程度,酒精使用史和尿液乙烯基葡萄糖胺水平.
- 采用多变量逻辑回归来分析与CSCI的关联.
主要成果:
- 41%的SMI-AUD样本显示CSCI,明显高于15%的规范率.
- 执行功能,特别是那些通过侧面和维度变化卡片排序测试测量的执行功能,最常见的是受损.
- 头部损伤史,AUD症状严重程度更高,负面症状严重程度更高与CSCI有显著的关联.
结论:
- 认知功能是管理SMI-AUD个体的关键考虑因素.
- 应特别注意有脑损伤史,高AUD严重程度和/或显著负面精神症状的患者.
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