针对伊朗土著羊品种的链接不平衡,种群结构和近亲繁殖的全基因组研究
S Barani1, A Nejati-Javaremi1, M H Moradi2
1Department of Animal Science, University College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran.
PloS one
|June 2, 2023
概括
使用SNP数据分析了伊朗绵羊品种的遗传多样性和近亲繁殖. 泽尔品种表现出更高的多样性和有效种群规模,而巴鲁奇品种表现出更高的近亲繁殖,可能是由于人工选择.
科学领域:
- 动物遗传学动物遗传学
- 人口遗传学 人口遗传学
- 基因组学就是基因组学.
背景情况:
- 了解链接不平衡 (LD),遗传结构和多样性对于研究土著小反动物的繁殖历史至关重要.
- OvineSNP50珠芯片阵列为羊的基因组分析提供了一个高密度的平台.
研究的目的:
- 为了估计和比较LD,基因多样性,有效种群大小 (Ne) 和三种伊朗土著羊品种的基因组杂交:Baluchi,Lori-Bakhtiari和Zel.
- 通过基因组数据阐明这些品种的遗传结构和繁殖历史.
主要方法:
- 用OvineSNP50珠芯片阵列分析了伊朗三种绵羊品种的186个个体的基因组DNA.
- 进行主要成分分析 (PCA) 和添加剂分析以评估遗传结构.
- 估计了链接不平衡 (LD),异构性,有效种群大小 (Ne) 和基因组内生育 (FROH).
主要成果:
- PCA证实了特定品种的聚类,混合物分析确定了三个不同的基因组 (K=3).
- 平均相邻的SNP r2值表明不同品种的LD水平不同,Baluchi显示较高的值.
- 泽尔品种表现出最高的异构性和Ne,而Baluchi品种显示出最高的基因组内生殖 (FROH),表明强大的人工选择压力.
结论:
- 巴鲁奇品种的高近亲繁殖和LD表明了增加的哈普洛型共享和人工选择的影响.
- 泽尔品种表现出更大的遗传多样性和更大的有效种群规模.
- 泽尔和洛里-巴赫蒂亚里品种表现出高的LD阶段持久性,表明在多品种基因组选择培训种群中联合使用的潜力.
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