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Updated: Jul 28, 2025

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
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免疫工程外细胞囊泡调节T细胞激活在1型糖尿病的背景下1型糖尿病

Matthew W Becker1, Leeana D Peters2,3, Thinzar Myint2,3

  • 1J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL.

Science advances
|June 2, 2023
PubMed
概括

工程外细胞囊泡 (EVs) 可以调节T细胞用于1型糖尿病免疫疗法. 用HLA-A2和CD80激活T细胞的设计EV,同时添加PD-L1诱导免疫调节反应.

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Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
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