在转移性激素敏感前列腺癌的早期治疗强化
Jeremiah Wala1, Paul Nguyen1, Mark Pomerantz1
1Dana-Farber Cancer Institute, Boston, MA.
概括
三重疗法,结合雄激素剥夺疗法 (ADT) 与多塞和一种雄激素受体通路抑制剂 (ARPI),改善了转移性激素敏感前列腺癌 (mHSPC) 的结果. 这种方法对患有高体积疾病的患者尤其有益.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 临床试验 临床试验
背景情况:
- 抗雄激素剥夺疗法 (ADT) 是治疗转移性激素敏感前列腺癌 (mHSPC) 的基石.
- 最近的试验显示,在ADT单一治疗之外,加强治疗策略的治疗结果有所改善.
- 双重疗法 (ADT加上多塞塔塞尔或ARPI) 与单独的ADT相比,提供了生存优势.
结论:
- 三重疗法是mHSPC的有价值的治疗强化,特别是在高体积疾病中.
- 在可行的情况下,对于低体积的mHSPC,积极使用放射治疗 (RT) 是有利的.
- 治疗决策应考虑疾病体积,风险概况和患者适合化疗.
相关概念视频
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Combination Therapies and Personalized Medicine
5.0K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K


