来自内性真菌的三种新的 furanones
Jia Lv1,2,3, Hong Zhou4,5, Limei Dong6
1School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Natural product research
|June 2, 2023
概括
这项研究从内性真菌Hypoxylon vinosopulvinatum中分离出新的 furanones. 氧 B 和 C 具有强大的抗真菌活性,可以对抗 Lasiodiplodia pseudotheobromae.
科学领域:
- 菌类学 菌类学是指菌类学.
- 自然产品 化学 化学
- 化学生态化学生态学
背景情况:
- 像Hypoxylon vinosopulvinatum这样的内生真菌,从Cinnamomum cassia中分离出来,可以产生生物活性化合物.
- Lasiodiplodia pseudotheobromae是一种植物病原体,导致农业的重大损失.
研究的目的:
- 从Hypoxylon vinosopulvinatum中分离和描述二次代谢产物.
- 评估隔离化合物的抗真菌潜力,以对抗植物致病菌和人类致病菌.
主要方法:
- 从Cinnamomum cassia中分离的真菌内生植物Hypoxylon vinosopulvinatum. 这是一种真菌.
- 使用乙烯酸乙烯提取和净化化合物.
- 使用UV,IR,1D,2D-NMR,HR-ESI-MS和ECD分析进行结构阐明.
- 针对Lasiodiplodia pseudotheobromae,Fusarium oxysporum和Candida albicans的抗真菌生物测试. 这是一个非常好的方法.
主要成果:
- 确定了三种新的 furanones, hypoxylonone A-C (1-3),以及三种已知的化合物 (4-6).
- 乙氧基隆 B 和 C 具有强烈的抑制作用,可以抑制拉西奥迪普洛迪亚 伪 (Lasiodiplodia pseudotheobromae) (IC50 = 1.01 和 2.40 μg/mL).
- 化合物6对Fusarium oxysporum (IC50 = 10.67μg/mL) 具有中等活性,而化合物3和4对Candida albicans表现出活性.
结论:
- 氧葡萄是新型抗真菌氨酸的来源.
- 乙氧基隆 B 和 C 是控制 Lasiodiplodia pseudotheobromae 感染的有希望的候选物.
- 需要对这些化合物的作用机制和潜在应用进行进一步的研究.
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