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膀癌新辅助化疗前明显完整的经尿道切除的瘤学结果

Bryce Baird¹, Ahmet Bilgili¹, Augustus Anderson²

¹Department of Urology Mayo Clinic, Jacksonville, FL, USA.

International braz j urol : official journal of the Brazilian Society of Urology

|June 2, 2023

概括

在新辅助化疗 (NAC) 和激进囊切除术 (RC) 之前,膀瘤的完全通过尿道切除 (TURBT) 并没有改善结果. 这些发现表明,当计划NAC和RC时,可能不需要重复TURBT.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
在瘤学瘤学.
手术瘤学手术瘤学

背景情况:

新辅助化疗 (NAC) 随后的激进囊切除术 (RC) 是肌肉侵入性膀癌的标准治疗方法.
在NAC和RC之前,膀瘤的完全通过尿道切除 (TURBT) 的作用尚不清楚.

研究的目的:

在NAC和RC之前评估明显完整的TURBT对瘤的益处.
为了确定完整的TURBT是否会影响病理下降阶段,完整反应或生存结果.

主要方法:

在2011-2021年期间接受NAC和RC的153名患者的回顾性审查.
评估TURBT的完整性,包括病理下降阶段 (
用物流回归和考克斯比例危险模型进行分析.

主要成果:

在76%的患者中实现了完整的TURBT.
在完整和不完整的TURBT组之间没有观察到病理下降阶段 (
完整的TURBT与癌症特异性或无复发生存率无关,但不完整的TURBT与所有原因死亡率的更高风险有关 (HR 1.77).

结论:

在NAC和RC之前明显完成的TURBT与改善的病理下降阶段或生存结果无关.
这些发现不支持在计划进行NAC和RC时需要重复TURBT以实现完全切除的常规需求.

关键词:

囊切除术 (Cystectomy) 是一种切除囊的方法.新辅助疗法是一种新辅助疗法.通过尿道切除膀.

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