费城染色体阳性骨髓质疏松症综合征与单一谱系失育症
Ajeet Kumar1, Vijai Tilak2, Disha Arora3
1Centre for Genetic Disorders, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India.
Cancer genetics
|June 2, 2023
概括
费城染色体阳性骨髓发育综合征 (Ph+ MDS) 是一种罕见的血液疾病. 这项研究回顾了两个新发病例,强调了这种不常见的MDS亚型的罕见性和诊断挑战.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
背景情况:
- 骨髓发育综合征 (MDS) 包括获得的克隆性造血干细胞疾病.
- 费城染色体 (Ph+),其特征是t(9;22) 和BCR-ABL融合,通常与慢性髓性白血病 (CML) 相关,但可以发生在其他髓性和淋巴性恶性瘤中.
- 费城染色体阳性骨髓发育综合征 (Ph+ MDS) 异常罕见,大多数记录的病例是在白血病进展期间出现的,很少有人出现de novo.
结论:
- 新生Ph+MDS的诊断和管理由于其罕见性而带来了独特的挑战.
- 需要进一步的研究来阐明Ph + MDS的临床行为和最佳治疗策略.
- 这些案例有助于对新生Ph+ MDS及其在MDS频谱中的位置的有限理解.
更多相关视频
12:05Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation
Published on: November 3, 2018
11.7K
09:01Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
14.0K
相关概念视频
01:21Lineage Commitment
3.0K
Commitment is the process whereby stem cells:
3.0K
01:15Differentiation of Common Myeloid Progenitor Cells
3.3K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.3K