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Updated: Jul 28, 2025

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变化的拓性质及其与单边叶的认知功能的关系

Keran Ma¹, Xiaonan Zhang¹, Chengru Song¹

¹Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China; Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China; Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China; Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China; Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China; Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China.

Epilepsy & behavior : E&B

|June 2, 2023

概括

叶 (TLE) 破坏整个大脑的功能网络,左侧TLE显示效率降低,右侧TLE显示故障耐受性受损. 网络变化与认知缺陷和疾病严重程度相关.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
的研究研究.

背景情况:

单侧叶 (TLE) 与海马硬化是一个常见的综合征.
了解TLE中网络层次的大脑变化对于解释认知障碍至关重要.

研究的目的:

为了研究带有海马硬化症的单边TLE的拓性质异常.
探索改变网络属性和认知功能之间的相关性.

主要方法:

休息状态功能磁共振成像 (fMRI) 用于38名TLE患者和19名健康对照 (HCs).
构建了全脑功能网络,并将它们的拓特征与左TLE,右TLE和HCs进行了比较.
分析了拓性质和认知测量之间的相关性.

主要成果:

与HC相比,左TLE患者的全球和局部效率下降.
右TLE患者在奖励/情绪和腹部注意力网络中表现出局部效率下降和节点中心性的改变.
在基底和默认模式网络中观察到特定的网络变化,其中有一些侧向差异.

结论:

全脑功能网络的拓性质在TLE中被破坏,侧面化影响网络特征.
左侧的TLE显示网络效率下降,而右侧的TLE显示故障耐受性和补偿机制受损.
这些发现提供了对TLE和认知障碍的横向化影响的见解.

关键词:

认知认知认知功能性磁共振成像技术功能性磁共振成像技术图形理论中的图形理论.在叶发作.

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