儿童间歇性肺病:多检测器计算机断层扫描模式和成像和组织病理学之间的相关性
Päria Miraftabi1, Turkka Kirjavainen2, Janne S Suominen3
1HUS Medical Imaging Center, Radiology, University of Helsinki and Helsinki University Hospital, Finland.
多检测器计算机断层扫描 (MDCT) 模式在儿童间歇性肺部疾病 (CHILD) 中很少被发现. 然而,当一个可识别的MDCT模式存在时,它可以准确地预测儿童儿童的最终诊断.
科学领域:
- 儿科肺病学 儿科肺病学
- 放射学 放射学是一门学科.
- 罕见疾病 罕见疾病
背景情况:
- 儿童间歇性肺病 (chILD) 涵盖了儿童群体独特的各种罕见肺部疾病.
- 诊断依赖于临床发现,多探测器计算机断层扫描 (MDCT),遗传分析,肺功能测试和肺活检.
- 在儿童中MDCT模式识别的诊断实用性仍未得到充分探索.
研究的目的:
- 调查组织学证实间歇性肺病的儿童中特定MDCT模式的患病率.
- 评估识别的MDCT模式的预测价值,用于最终的CHILD诊断.
主要方法:
- 对90名儿科患者 (2004-2020年) 的活检,MDCT和临床数据的回顾性分析.
- 蒙蔽专家审查了MDCT图像.
- 组织学发现被根据已建立的chILD类别进行分类.
主要成果:
- 其中90名患者中有63%是男性,活检年龄中位数为1.3岁.
- 确定了六种不同的MDCT模式:婴儿期的神经内分泌细胞增生,组织性肺炎,非特异性间歇性肺炎,支气管炎,肺膜蛋白质性,支气管肺部发育不良等.
- 在43%的患者中存在可识别的MDCT模式;其中,87%的患者具有预测最终诊断的模式. 在57%的病例中,没有特定的模式被识别出来.
结论:
- 特定的MDCT模式在不到一半的儿童间歇性肺病病例中被确定.
- 当在儿童中识别出明显的MDCT模式时,它对最终诊断具有显著的预测价值.
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