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Updated: Jul 28, 2025

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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对CDK2抑制的快速适应暴露了细胞周期内在的可塑性

Mansi Arora1, Justin Moser1, Timothy E Hoffman1

  • 1Department of Biochemistry and BioFrontiers Institute, University of Colorado-Boulder, Boulder, CO 80303, USA.

Cell
|June 2, 2023
PubMed
概括

在癌细胞中,循环素依赖性激酶2 (CDK2) 抑制剂呈现出快速的基质酸化损失,但发生适应. 补偿CDK4/ 6活性,这表明需要联合CDK2和CDK4/ 6抑制才能有效治疗癌症.

关键词:
CDK 的可塑性CDK2 其他CDK4/6 其他现在,我已经知道了.现在,我已经知道了.帕尔波西西布其他环素A药物适应限制点

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