增长速度是否会影响出生体重和神经发育之间的关系,对于非常早产的婴儿?
Thibaut Sériès1, Mireille Guillot2, Georgina Angoa2
1School of Psychology, Université du Québec à Trois-Rivières, Trois-Rivières, Canada.
The Journal of pediatrics
|June 2, 2023
概括
新生儿生长速度部分介于早产婴儿出生体重和神经发育之间的联系. 较高的生长速度与更好的认知和语言成绩有关,特别是在低出生体重的婴儿中.
科学领域:
- 新生儿科学 新生儿科学
- 发育儿科 发育儿科
- 围产儿医学 围产儿医学
背景情况:
- 出生体重和新生儿生长速度是影响早产婴儿神经发育结果的关键因素.
- 了解这些因素之间的相互作用对于优化长期认知和语言发展至关重要.
研究的目的:
- 调查新生儿生长速度在出生体重和神经发育结果之间的关联中的调解作用.
- 检查成长速度如何影响非常早产婴儿的认知和语言得分.
主要方法:
- 对MOBYDIck随机试验的二次分析,涉及怀孕29周以下的婴儿.
- 使用贝利-III认知和语言分数评估的神经发育结果,年龄在18-22个月纠正.
- 使用因果调解和线性回归模型来分析生长速度的作用,并根据出生体重百分点对子组进行分析.
主要成果:
- 增长速度部分介于出生体重与认知 (β = -1.1) 和语言 (β = -2.1) 分数之间的关系.
- 每1g/kg/day增长的增长速度与更好的认知和语言得分相关.
- 最低出生体重百分位数 (<25位) 的婴儿在认知和语言得分上表现出显著更大的改善,增长速度增加.
结论:
- 产后生长速度在出生体重与神经发育结果关系中起着重要的调解作用.
- 促进更高新生儿生长速度的干预措施可能对出生体重较低的非常早产婴儿特别有益,以提高神经发育性能.
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