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相关概念视频

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The Problem-Oriented Medical Record (POMR) revolutionized medical record-keeping by introducing a systematic approach focusing on the patient's problems rather than merely listing symptoms. Dr. Lawrence Weed's introduction of this method in the 1960s marked a significant advancement in medical documentation. The POMR framework consists of four key components: the database, problem list, plan of care, and progress notes.
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Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model
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没有PMPM吗?

Yanan Cao1, Tianzi Zang2, Tianlai Qiu2

  • 1School of Public Health, Wuhan University, Wuhan, 430071, China.

Environmental research
|June 2, 2023
PubMed
概括

孕期暴露于细颗粒物 (PM1) 对新生儿肠道微生物群的多样性和组成产生影响. 这项研究揭示了对新生儿肠道细菌和代谢途径的显著影响,突出了对母亲和婴儿健康的潜在影响.

关键词:
环境粒子 环境粒子我们的肠道微生物群.宫内发育的子宫内发展新生儿是一种新生儿.总理 (PM) 总理 (PM) 一,怀孕 怀孕 怀孕 怀孕

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科学领域:

  • 环境健康 环境健康
  • 微生物组研究 微生物组研究
  • 围产期流行病学 围产期流行病学

背景情况:

  • 关于产前暴露于细颗粒物 (PM1) 对母体和新生儿肠道微生物群的影响的流行病学数据有限.
  • 以前的研究表明,环境空气污染物可以改变6个月龄的婴儿的肠道微生物群.

研究的目的:

  • 调查孕期暴露于PM1与母亲和新生儿肠道微生物群的组成和功能之间的关联.
  • 提供有关怀孕期间PM1暴露影响的流行病学证据.

主要方法:

  • 在中国中部的一个母婴队列被用来估计基于住宅地址的PM1暴露.
  • 用16SrRNA测序分析了肠道微生物群,通过Tax4fun.fun评估了功能途径.
  • 多重线性回归和PERMANOVA被用来评估PM1对微生物多样性,组成和功能的影响,控制其他污染物.

主要成果:

  • 孕期PM1暴露与新生儿肠道微生物群α多样性正相关,解释了14.8%的社区组成差异.
  • 暴露于PM1并没有影响母亲肠道微生物群的多样性或组成.
  • 特定的细菌种群 (母体中的Actinobacteria;新生儿中的Clostridium_sensu_stricto_1,Streptococcus,Faecalibacterium) 和代谢途径 (,双成分系统,Pyruvate,Purine,Aminoacyl-tRNA生物合成,Pyrimidine,Ribosome) 发生了显著的改变.

结论:

  • 这项研究提供了第一个证据,将产前PM1暴露与母亲和新生儿肠道微生物群的显著变化联系起来.
  • 新生儿麦科尼微生物群的多样性,组成和功能特别受到妊娠期PM1暴露的影响.
  • 这些发现强调了在母亲健康管理和未来婴儿健康结果中考虑PM1暴露的重要性.