D-二次测试:一个叙事审查
L Wauthier1, J Favresse2, M Hardy3
1Department of Laboratory Medicine, Clinique St-Luc Bouge, Namur, Belgium.
Advances in clinical chemistry
|June 2, 2023
概括
D-二聚体是血栓形成和分解的生物标志物,主要用于排除静脉血栓塞栓症 (VTE). 本次审查涵盖了D-二聚合物.
科学领域:
- 生物化学 生物化学
- 血液学 血液学 血液学
- 临床诊断 临床诊断 临床诊断
背景情况:
- D-二元体代表纤维素降解产物,表明凝血和纤维素分解的激活.
- 它的主要临床效用在于排除静脉血栓塞栓症 (VTE).
- 对于VTE复发风险,抗凝血持续时间,扩散性血管内凝血 (DIC) 诊断和VTE风险查,D-二聚体也在被探索.
研究的目的:
- 定义D-二次体及其作为生物标记物的作用.
- 讨论影响D-二聚合物试验的分析前和分析后变量.
- 审查D-二聚体测定性能及其在各种临床环境中的应用.
主要方法:
- 对D-二聚体现有的文献进行叙述性综述.
- 对D-二次体定义,测量变量和试验性能进行分析.
- 讨论临床应用和特定患者群体.
主要成果:
- D-二聚体是凝血和纤维素分解的关键标记物.
- 分析前和分析后的因素显著影响D-二次元结果.
- 测试性能各不相同,需要遵守预期使用和监管指南.
结论:
- D-二分子是一种有价值的诊断工具,特别是在排除VTE时.
- 标准化测试性能和适当的解释对于可靠的结果至关重要.
- 需要进一步的研究,以优化在特定的临床场景,如怀孕,癌症和COVID-19中D-二聚合物的使用.
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