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附着和消失的病原体调节宿主线粒体的结构和功能.

Anusha Harishankar1, V K Viswanathan2

  • 1School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, United States.

International review of cell and molecular biology
|June 2, 2023
PubMed
概括
此摘要是机器生成的。

肠病原性和肠出血性大肠杆菌使用III型分泌系统来输送改变宿主细胞线粒体的效应物. 了解这些线粒体效应是破译细菌病原和开发治疗方法的关键.

关键词:
附着-消除 (A/E) 病原体的病原体细胞死亡 细胞死亡在Citrobacter rodentium的研究中,EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC EPEC肠道上皮质 肠道上皮质线粒体膜潜在的潜力线粒体形态学 线粒体形态学氧化酸化是一种氧化酸化.第3类分泌系统.

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科学领域:

  • 微生物学 微生物学
  • 细胞生物学 细胞生物学
  • 病变的发生和发病.

背景情况:

  • 肠病原性 (EPEC) 和肠出血性 (EHEC) 大肠杆菌是人类重要的肠道病原体.
  • 这些细菌与Citrobacter rodentium一起,是利用III型分泌系统 (T3SS) 的"附着和消除" (A/E) 病原体.
  • T3SS将效应蛋白送入宿主细胞,这对细菌殖民和疾病至关重要.

研究的目的:

  • 为提供由A/E病原体诱导的宿主细胞变化的概述.
  • 专注于细菌效应剂对宿主细胞线粒体的影响.
  • 突出线粒体在A/E细菌病原发生中的关键作用.

主要方法:

  • 对详细介绍效应因子与线粒体相互作用的体外研究的综述.
  • 在体内研究的分析,主要使用Citrobacter rodentium/小鼠模型.
  • 检查宿主细胞的修饰,包括线粒体形态,功能和亡.

主要成果:

  • 细菌效应器直接准线粒体,改变形态,氧化酸化和ROS生产.
  • 观察到线粒体膜潜力的破坏和内在亡的诱导.
  • 活体研究证实了一些体外发现,并表明肠道的更广泛的生理变化.

结论:

  • 线粒体修饰是A/E病原体引起疾病的中心机制.
  • 解读效应体-线粒体相互作用对于理解病变发生是必不可少的.
  • 需要进一步的研究来确定体内线粒体变化的机制基础.