排除横向和垂直传输作为主要电源的排除
Whitney M Kiehl1, Carolyn L Hodo2, Gabriel L Hamer3
1Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas.
Comparative medicine
|June 2, 2023
概括
导致查加斯病的寄生虫Trypanosoma cruzi主要感染美国南部的户外非人类灵长类动物 (NHP). 当地三体载体,而不是从动物传播到动物,是的主要感染来源.
科学领域:
- 兽医流行病学 兽医流行病学
- 寄生虫学的寄生虫学
- 野生动物健康 野生动物健康
背景情况:
- 草虫 (Trypanosoma cruzi) 导致查加斯病,对美国南部生物医疗设施的户外非人类灵长类动物 (NHP) 构成风险.
- 感染可以导致令人困惑的病理生理变化,限制研究效用,有时导致动物杀.
- 美国没有关于在囚禁NHP中动物间传播 (水平或垂直) 的数据.
研究的目的:
- 为了评估T. cruzi在被囚禁的中动物间传播的潜力.
- 确定影响新感染分布的环境因素.
- 推断水平或垂直传输路线的重要性.
主要方法:
- 在德克萨斯州南部的一个 rhesus macaque 繁殖殖社的回顾性流行病学研究.
- 分析已存档的生物样本和养殖记录,以确定血清转化时间和地点.
- 空间分析以评估地理位置和动物协会对疾病传播的影响.
主要成果:
- 大多数T. cruzi感染在空间上聚集在一起,这表明环境因素促进了载体暴露.
- 横向传播没有被确定为疾病传播的关键途径.
- 垂直传播并不是这种子殖民地的一个因素.
结论:
- 当地的三体载体是T. cruzi感染的主要来源,在这个殖民地,在被囚禁的子中.
- 防止与载体接触是对户外的疾病控制的关键策略.
- 隔离受感染的比病媒控制对预防疾病来说不那么重要.
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