在器官移植接收者中的真菌菌
Niyati Narsana1, María Alejandra Pérez2, Aruna Subramanian3
1UC Davis School of Medicine, 4150 V Street, G500, Sacramento, CA 95817, USA.
Infectious disease clinics of North America
|June 2, 2023
概括
固体器官移植接受者面临结核病的风险. 早期查和对潜伏性结核病和其他真菌细菌感染的仔细管理至关重要,特别是在药物相互作用的情况下.
科学领域:
- 传染性疾病 传染性疾病
- 移植医学 移植医学
- 公共卫生 公共卫生
背景情况:
- 固体器官移植 (SOT) 接受者是感染的脆弱人群.
- 由于免疫抑制,结核病 (TB) 在SOT接受者中构成重大风险.
- 其他难以治疗的真菌细菌,如Mycobacterium abscessus和Mycobacterium avium复合体,也带来了挑战.
研究的目的:
- 审查SOT接受者的结核病流行病学和风险因素.
- 概述了移植前结核病查和潜在结核病管理的策略.
- 在这个队列中讨论管理结核病和其他真菌细菌感染的复杂性.
主要方法:
- 文献审查侧重于流行病学数据和临床管理指南.
- 分析与移植后结核病发展相关的风险因素.
- 检查治疗挑战和药物相互作用.
主要成果:
- 在SOT接受者中确定结核病的关键风险因素.
- 强调移植前查和潜伏性结核病治疗的重要性.
- 突出管理传播性结核病和非结核菌的挑战.
- 注意到里法米辛与免疫抑制剂之间存在显著的药物相互作用.
结论:
- 积极的结核病查和管理对SOT接受者至关重要.
- 由于可能与免疫抑制疗法的药物相互作用,需要仔细监测.
- 治疗结核病和其他真菌细菌感染需要在移植患者中采取量身定制的方法.
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