抗指导方针:我们是否纳入了有关卡博普拉丁和人环素的变化?
Susana Redondo Capafons1, Laura Soriano Gutierrez1, Elsa Dalmau Portulas2
1Servicio de Farmacia Hospitalaria, Corporació Sanitària Parc Taulí, Sabadell, España.
这项研究发现,网皮坦/帕洛诺塞特朗 (NEPA) 与德克萨米他 (NEPAd) 是一种具有成本效益的抗选择,在预防化疗诱导的恶心和吐 (CINV) 方面显示出与其他疗法相似的有效性. 使用NEPAd可以节省大量的成本,同时保持对CINV.患者的高度保护.
科学领域:
- 在瘤学瘤学.
- 药物经济学 药物经济学
- 临床药房 临床药房
背景情况:
- 2016年MASCC/ESMO指导方针推用于高排泄性化疗 (HEC) 和碳白金疗法的三重抗疗法.
- 根据这些指导方针评估当前的临床实践对于优化抗emetic预防至关重要.
研究的目的:
- 评估MASCC/ESMO指导方针与HEC和碳烯的实际抗性预防之间的一致性.
- 为了评估抗治疗方案的有效性.
- 为了确定使用netupitant/palonosetron (NEPA) 口服/静脉注射 (iv) 与德甲 (NEPAd) 相比IV使用Fosaprepitant与Ondansetron和德甲 (FOD) 的成本节省 (IV).
主要方法:
- 进行了一项前性观察性研究,记录了患者的人口统计,化疗, emetogenic 风险和处方抗emetics.
- 评估了与MASCC/ESMO指南的一致性,通过MASCC调查的有效性,救援药物的使用和紧急访问.
- 进行了成本最小化药物经济分析.
主要成果:
- 包括61名患者;21.1%的治疗方案最初偏离了指南.
- 报告的高效率为:急性恶心的90.9%,急性吐和延迟恶心的100%,延迟吐的72.7%.
- 救援药物使用率从18.7%下降到0%,没有紧急访问或住院治疗.
结论:
- 与FOD iv相比,NEPAd的成本降低了28%,这表明节省了大量资金.
- 观察到指导方针与临床实践之间有很高的一致性.
- 这两种抗疗法在临床实践中都显示出相似的有效性,NEPAd提供了一个高效和成本效益的选择.
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