乳腺癌之后的第二次原发性肺癌患者的特征:一项回顾性描述性研究
Kevin Yu Wang1, Chung-Shien Lee1, Prashant Vempati1
1Northwell Health/Zucker School of Medicine, Hofstra/Northwell, Manhasset, NY.
Clinical lung cancer
|June 2, 2023
概括
乳腺癌幸存者面临患肺癌 (LC) 的风险更高,特别是在放射治疗后. 像BRCA突变和吸烟这样的遗传因素也会增加这些患者的LC风险.
科学领域:
- 在瘤学瘤学.
- 癌症流行病学 癌症流行病学
背景情况:
- 乳腺癌 (BC) 是女性最常见的癌症.
- 患有BC的幸存者患有二次恶性瘤的风险较高,最常见的是肺癌 (LC).
- 关于BC幸存者的LC临床病理细节的研究有限.
研究的目的:
- 研究乳腺癌幸存者的肺癌临床病理学特征.
- 将这些特征与一般的BC和LC种群进行比较.
- 在乳腺癌幸存者中识别二次肺癌的风险因素.
主要方法:
- 一个机构,回顾性研究.
- 鉴定BC幸存者谁发展LC.
- 检查乳房和LC的临床/病理数据.
- 与一般BC和LC群体的文献数据进行比较.
主要成果:
- 对BC的放射治疗与LC的风险增加有关 (P = .03对于ipsilateralLC).
- 更高的吸烟率与LC发病率的增加相关.
- 在测试患者中观察到高的BRCA阳性 (78.9%).
- 在BC幸存者中,增加了EGFR突变 (60.9%) 和早期NSCLC.
结论:
- 辐射,BRCA突变和吸烟是BC幸存者中LC的潜在危险因素.
- 进一步的研究可能会完善查协议 (例如,低剂量CT) 以早期检测LC.
- 在BC幸存者的EGFR突变NSCLC表明潜在的更好的预后和独特的分子形状.
- 在这个队列中早期的NSCLC可能是由于监测,强调监测BC幸存者的重要性.
关键词:
这就是BRCA BRCA.乳腺癌是什么? 乳腺癌是什么化疗 化疗是一种化学疗法.欧洲农业基金会 (EGFR) 是一个基金.激素治疗是一种激素治疗.肺癌是一种肺癌.辐射辐射辐射的辐射是什么吸烟 吸烟 吸烟 吸烟更多相关视频
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