在老年人认知训练期间重复脑刺激后的微观结构和功能可塑性
Daria Antonenko1, Anna Elisabeth Fromm2, Friederike Thams2
1Department of Neurology, Universitätsmedizin Greifswald, Greifswald, Germany. daria.antonenko@med.uni-greifswald.de.
Nature communications
|June 2, 2023
概括
在老年人中,将认知训练与跨直流刺激 (tDCS) 结合起来,增强了大脑白质微观结构. 这些大脑变化预测了在未经训练的任务上表现的提高,揭示了tDCS的关键机制.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 神经成像是一种神经成像.
背景情况:
- 跨直流刺激 (tDCS) 与行为训练相结合,可能会增强超出训练任务的脑功能.
- 这些综合干预措施背后的精确神经机制在很大程度上仍未被探索.
研究的目的:
- 研究神经生物学机制,即同时进行认知训练和阳极tDCS调节老年人大脑功能.
- 探索大脑微观结构和功能连接的变化如何与训练有素和未训练有素任务的行为改进有关.
主要方法:
- 这是一项单盲,随机,安慰剂对照试验,涉及48名老年人.
- 参与者接受了为期三周的执行功能培训,并与道tDCS或假tDCS相结合.
- 多模式磁共振成像 (MRI) 用于评估干预前后的大脑结构和功能.
主要成果:
- 阳道tDCS与认知训练相结合,调节了前额前白质微观结构,变化预测了转移任务的性能增长.
- 在训练加tDCS后,在刺激部位的灰质微观结构变化和前额功能连接的增加被观察到.
- 研究结果表明,tDCS影响纤维组织,髓形成,质和突触过程以及网络同步.
结论:
- 这项研究为结合认知训练与tDCS的效果提供了机制性的见解.
- 这些发现突出了tDCS诱导的白质微观结构和功能连接性的改变,作为认知转移的关键驱动因素.
- 这些结果支持tDCS的有针对性的应用,用于在临床和实验环境中增强神经网络调制.
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