神经成像谷氨酸干细胞机制,区分抗精神病治疗反应和治疗反应
Elias D Mouchlianitis1,2, Lucy D Vanes3, Derek K Tracy4,5,6
1Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, SE5 8AF, UK. e.mouchlianitis@uel.ac.uk.
Scientific reports
|June 2, 2023
概括
谷氨酸功能障碍区分了治疗耐药精神分裂症和治疗响应的形式. 神经成像揭示了奖励通路中的独特的大脑活动模式,提供了潜在的诊断见解.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 谷氨酸功能障碍与精神分裂症中抗精神病治疗耐药性有关.
- 了解神经化学和功能性大脑变化对于个性化治疗至关重要.
研究的目的:
- 研究治疗耐药精神分裂症 (TRS) 与治疗反应性精神分裂症 (TR) 和健康对照中的谷氨酸功能障碍和奖励处理.
- 结合神经化学和功能性脑成像,以区分患者群体.
主要方法:
- 60名参与者 (21名TRS,21名TR,18名对照组) 在信任任务中接受了功能磁共振成像 (fMRI).
- 质子磁共振光谱 (MRS) 测量了前环皮质 (ACC) 中的谷氨酸.
主要成果:
- 与对照组相比,TR和TRS组在信任任务期间的投资减少.
- 与TR和对照组相比,TRS患者在ACC中表现出谷氨酸水平的改变,与前额叶皮层 (PFC) 和皮层活动的减少有关.
- 与TRS和对照组相比,TR患者的前尾腺活动减少.
结论:
- 谷氨酸在ACC中的差异区分了治疗抵抗性精神分裂症和治疗反应性精神分裂症.
- 不同的皮层和皮层下奖励学习基质可能具有诊断潜力.
- 在奖励网络中准神经递质提供了一个未来的治疗途径.
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