胃肠道症状与成年人性结肠炎内镜-组织学疾病活动之间的相关性
Chung Sang Tse1, Hang P Nguyen2, Siddharth Singh3
1Division of Gastroenterology, University of Pennsylvania, 11th Floor Penn Medicine University City, 3737 Market Street, Philadelphia, PA, 19104, USA. chung.tse@pennmedicine.upenn.edu.
Digestive diseases and sciences
|June 2, 2023
概括
在深度缓解的性结肠炎患者中,四分之一仍有胃肠道症状,主要是腹. 内分组织炎症准确地预测了活跃疾病的症状.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 临床结果 临床结果
背景情况:
- 胃肠道 (GI) 症状和内镜炎症之间的不一致性在性结肠炎 (UC) 中被认可.
- 症状与UC的结合内镜和组织学 (内-组织学) 粘膜愈合之间的关系尚不清楚.
研究的目的:
- 调查患者报告的胃肠道症状与UC粘膜愈合的客观指标之间的相关性.
- 评估内分泌组织炎症和临床症状对疾病活动的预测价值.
主要方法:
- 在2014-2021年期间,从254次结肠镜 (179名成年人) 收集的数据进行了二次分析.
- 在患者报告的结果 (PRO-2) 和客观评估 (UCEIS,Geboes分数) 之间使用斯皮尔曼等级评估相关性.
- 对炎症和症状的计算灵敏度,特异性和预测值.
主要成果:
- 28%的病例实现了内组织学缓解,但25%报告了胃肠道症状 (22%的腹,6%的直肠出血).
- 对于临床活性疾病,内组织学活性疾病显示出高灵敏度 (≥87%) 和负预测值 (≥78%).
- PRO-2评分与内镜 (r=0.57) 和组织学 (r=0.49) 疾病活动正相关.
结论:
- 在深度缓解的UC患者中,很大一部分患有胃肠道症状,主要是腹.
- 内体组织炎症是预测UC患者活跃的胃肠道症状的敏感指标.
相关概念视频
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
161
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
161
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
227
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
227
01:17Assessment of the Gastrointestinal System I: Subjective Data
236
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
236
01:17Chronic Bowel Disorders: Introduction
493
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
493
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
365
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
365
01:30Inflammatory Bowel Disease II: Crohn's Disease
306
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
306