重症患者的高正常与低正常的平均动脉压值:随机试验的系统性审查和元分析
Kiran J K Rikhraj1,2, Claire Ronsley3, Mypinder S Sekhon4
1Department of Emergency Medicine, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada. k.rikhraj@alumni.ubc.ca.
这项研究发现,在重症患者中,高正常和低正常的平均动脉压 (MAP) 目标之间,死亡率,神经结果或置换疗法需求没有显著差异. 这些发现支持目前在重症监护机构管理血压的指导方针.
科学领域:
- 关键护理医学 关键护理医学
- 心血管生理学心血管生理学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 在重症患者中最佳的平均动脉压 (MAP) 目标仍在争论中.
- 之前的审查表明,较高的MAP目标对死亡率没有好处,但新的证据需要更新.
- 这项研究解决了围绕不同重症患者群体MAP目标的不确定性.
结论:
- 这一更新的元分析表明,针对高正常MAP与低正常MAP的向并不会改变严重病患者的死亡率,神经结果或脏替代疗法需求.
- 这些发现提供了适度确定性的证据,支持有关MAP管理的当前临床实践.
- 没有观察到研究之间的显著异质性,加强了汇总结果.
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