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Updated: Jul 28, 2025

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具有终端分化的效应体特征的Granzyme B + CD8 + T细胞决定了多发性硬化症的进展

Ziyan Shi1, Xiaofei Wang1, Jiancheng Wang1

  • 1Department of Neurology, West China Hospital, Sichuan University, No.28 Dianxin Nan Street, Chengdu, 610041, China.

Journal of neuroinflammation
|June 2, 2023
PubMed
概括

外围CD8+ T细胞,特别是GzmB+ CD8+ TEMRA细胞,与多发性硬化症 (MS) 的进展有关. 高GzmB+ CD8+ TEMRA细胞可以区分二级渐进性MS (SPMS) 和复发性复发性MS (RRMS).

关键词:
在CD8+TEMRA细胞中.克隆扩张 克隆扩张这是一个GzmBB.多发性硬化症是多发性硬化症.二次进展的二次进展.单细胞RNA测序的一个细胞.

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