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表观遗传加速年龄调解了吸烟和糖尿病相关结果之间的关联
Xue-Yong Chang1, Wan-Yu Lin2,3,4
1Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Room 501, No. 17, Xu-Zhou Road, Taipei, 100, Taiwan.
Clinical epigenetics
|June 2, 2023
概括
表观遗传衰老加速 (EAA) 措施,特别是像GrimEAA这样的第二代时钟,调节吸烟.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 基因组学就是基因组学.
- 公共卫生 公共卫生
背景情况:
- 吸烟是已知的肺功能下降和糖尿病易感性增加的风险因素.
- 吸烟会在特定的CpG位点诱导DNA甲基化 (DNAm) 变化.
- 表观遗传衰老加速 (EAA) 措施,如GrimEAA,受到DNAm的影响,并与衰老有关.
研究的目的:
- 调查EAA措施是否调解吸烟和健康结果之间的关系.
- 探索EAA具体措施在将吸烟与糖尿病和肺功能联系起来的作用.
- 在亚洲人群中分析这些关联.
主要方法:
- 包括来自台湾生物库的2474名参与者,吸烟,DNAm和健康数据.
- 分析了7个DNAm标记物,包括5个EAA测量 (HannumEAA,IEAA,PhenoEAA,GrimEAA,DunedinPACE).这些标记物包括在内.
- 进行调解分析,调整年龄,性别,BMI和生活方式因素等共变量.
主要成果:
- 第二代EAA措施 (GrimEAA,DunedinPACE,PhenoEAA) 显著调解了吸烟与糖尿病结局的关联.
- DNAm PAI-1水平调解了吸烟对强迫生命能力 (FVC) 的不良影响.
- 对于前吸烟者来说,更长的戒烟时间通过GrimEAA对FVC和通过PhenoEAA对FEV1产生了积极的影响.
结论:
- 第二代表观遗传钟 (GrimEAA,DunedinPACE,PhenoEAA) 是将吸烟与糖尿病联系起来的关键媒介.
- 第一代时钟 (HannumEAA,IEAA) 没有显示显著的调解效应.
- 吸烟直接和间接地通过DNAm驱动的衰老过程对健康产生不利影响.
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