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一种基于水凝的急救组织粘合剂,具有有效的血液静止和抗细菌,用于创伤应急管理

Dongjie Zhang¹, Li Mei², Yuanping Hao³

¹Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China.

Biomaterials research

|June 2, 2023

概括

一种新的碳甲基/聚甲基德克斯 (CMCS/PD) 水凝作为一种自我愈合的,抗菌的急救组织粘合剂. 这种新的水凝表现出快速凝,强,在血液静止和创伤管理的抗感染的卓越性能.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
再生医学是一种再生医学.

背景情况:

临床组织粘合剂面临的挑战是,对于紧急伤害而言,粘合强度和抗感染能力不足.
为了解决这些局限性,开发了一种新型的碳素甲基基托/聚甲基德克斯 (CMCS/PD) 水凝.

研究的目的:

设计和评估一种自我愈合和抗菌的CMCS/PD水凝作为急救组织粘合剂,用于创伤紧急管理.
评估水凝的特性,包括凝形成时间,多孔性,自我愈合,抗菌活性,细胞毒性,粘合强度和血液兼容性.

主要方法:

凝形成时间,多孔性,自我愈合,抗菌性质,细胞毒性,粘合强度和血液兼容性的体外表征.
使用大鼠模型进行肝脏出血,尾巴切断和皮肤伤口感染的体内评估.

主要成果:

该CMCS/PD水凝表现出快速凝 (~5秒),良好的自我愈合和有效的抗菌特性.
观察到高粘合强度 (~10 kPa) 和爆破压力 (327.5 mmHg),具有出色的血液兼容性和细胞兼容性.
与商业产品 (Surgiflo®和Prontosan®) 相比,水凝显示出优异的血液静止和抗感染作用.

结论:

该CMCS/PD水凝显示显著的希望作为急救组织粘合剂的创伤紧急情况.
它的快速凝形成能力也使得它适用于微创手术的液体急救带.

关键词:

这是一种抗感染药物.碳氧甲基基托桑是一种碳氧甲基基托桑.水凝是一种水凝.它可以自我治愈.组织粘合剂组织粘合剂创伤紧急情况

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