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双重任务步行成本与白物质高强度负担的关联 脑卒中后:ONDRI的结果
Frederico Pieruccini-Faria1, Benjamin Cornish2, Malcolm Binns3
1Gait and Brain Lab, St. Joseph's Hospital, Parkwood Institute, Lawson Health Research Institute, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Neurorehabilitation and neural repair
|June 3, 2023
概括
在中风后的个人中,双重任务步行成本 (DTC) 与更大的白质损伤有关,特别是在皮质下区域. 这一发现强调了DTC作为影响中风后步态和认知的神经变化的潜在指标.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 放射学 放射学是一门学科.
背景情况:
- 在认知任务 (双任务步行成本,DTC) 和白质超强度 (WMH) 期间的步行速度变化是老年人中风后残疾的关键预测因素.
- 在中风后,特定大脑区域的DTC和WMH体积之间的关系尚不清楚.
研究的目的:
- 为了研究双重任务步行成本 (DTC) 和白质超强度 (WMH) 在特定大脑区域的双重任务步行成本 (DTC) 和白质超强度 (WMH) 在具有中风史的个体之间的关系.
- 为了确定DTC是否与WMH的总体负担及其在中风后大脑中的分布有关.
主要方法:
- 一项队列研究包括123名有中风病史的老年人 (平均年龄69岁).
- 步行表现在单任务和双任务条件下进行评估,以计算DTC.
- 结构神经成像分析了WMH体积在额头,额头,头,叶和皮层下区域 (基底腺 + 甲状腺),并对多个共变量进行了调整.
主要成果:
- 在DTC和整体超强度负担 (WMH) 之间发现了显著的全球线性关联.
- 基底质 + 丘脑区域的WMH体积显著促进了这一关联,独立于大脑缩.
- 这些发现表明,在认知负载下步态变化与皮下白质损伤之间存在联系.
结论:
- 在中风后个体中增加的DTC可能表明更广泛的白质损伤,特别是在皮质下区域.
- 这种皮质下损伤可能会损害认知处理,减少步行的自动性,需要更大的皮质控制.
- 在中风后的人群中,DTC作为白质完整性和功能结果的潜在生物标志物.
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