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自焚纳米辅助剂用于在场疫苗接种免疫治疗结肠直肠癌

Weiqi Wang^1,2, Qiwen Zhu², Yilan Jin^1,2

¹School of Pharmacy, Nantong University, Nantong, Jiangsu Province, 226001, China.

Advanced healthcare materials

|June 3, 2023

概括

新的自焚纳米辅助剂通过释放类似收费受体7/8激动剂 (R848) 和使用光动力学疗法 (PPa) 来触发抗瘤免疫反应并减少副作用来增强癌症疫苗接种免疫疗法.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
材料科学材料科学材料科学

背景情况:

癌症疫苗接种免疫疗法显示出希望,但面临系统辅助毒性和免疫耐受性挑战.
可调节的免疫辅助剂是必要的,以提高疫苗的反应,同时最大限度地减少副作用.

研究的目的:

开发和评估自我焚烧的纳米辅助剂,以加强癌症疫苗接种免疫疗法.
研究光动力学治疗和向药物释放用于癌症治疗的协同效应.

主要方法:

通过联合组装resiquimod (R848) 和 pyropheophorbide a (PPa) 来设计的纳米辅助剂.
利用被动瘤向并触发酸性内分泌体中的药物释放.
应用671nm激光照射用于光动力学治疗和随后的R848释放.

主要成果:

纳米辅助剂诱导瘤细胞免疫性死亡,并以受控的方式释放R848.
树突细胞的协同激活,增强抗原交叉呈现,并招募细胞毒性T淋巴细胞.
在结直肠癌模型中,与免疫检查点阻塞的联合治疗导致了持续的免疫记忆和抑制瘤复发.

结论:

自焚纳米辅助剂为在位癌症疫苗接种免疫治疗提供了一个有希望的策略.
这种方法有效地刺激抗瘤免疫力,建立长期记忆,克服传统方法的局限性.

关键词:

抗原呈现的呈现方式.免疫性细胞死亡免疫性细胞死亡纳米助剂是一种纳米助剂.光动力学疗法是一种光动力学疗法.疫苗接种免疫疗法免疫疗法

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