在移动过程中,主要体感皮层神经元网络动态中的年龄和性别相关的变化
Sami L Case1, Ruei-Lung Lin1, Olivier Thibault1
1Department of Pharmacology & Nutritional Sciences, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Aging cell
|June 3, 2023
概括
大脑衰老涉及 (Ca2+) 的变化. 这项研究揭示了体感皮质中与年龄和性别相关的神经网络的改变,影响小鼠的运动稳定性.
科学领域:
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
- 信号传递 信号传递
背景情况:
- (Ca2+) 假设将海马Ca2+失调与大脑衰老和认知衰退联系起来.
- 以前的研究集中在单细胞和切片制剂上,因此需要对清醒动物进行研究.
- 目醒动物皮质中与年龄和性别有关的神经网络变化仍未得到充分研究.
研究的目的:
- 在清醒的,流动的小鼠中,研究初级体感皮质 (S1) 神经网络的年龄和性别依赖的变化.
- 探索S1神经元活动,Ca2+动态和运动稳定性之间的关系.
- 为了测试 Ca2+ 假设的大脑衰老在清醒行为动物中的概括性.
主要方法:
- 在漫游的C56BL/6J小鼠 (年轻成人和老年人) 的S1皮质中对GCaMP8f进行警觉两光子成像.
- 在行走和休息期间同时记录神经元活动.
- 步行行为分析,以评估成像后的发动机稳定性.
主要成果:
- 在行走期间,在年轻和老年小鼠中观察到网络连接和同步性增加.
- 老年男性的网络同步性呈现出年龄相关的增加.
- 与男性相比,女性表现出更高的神经元活动,更活跃的神经元,以及增加的Ca2+过渡物,特别是在行走过程中.
结论:
- S1 Ca2+ 动力学和网络同步性与保持运动稳定性有关.
- 在S1神经网络中,年龄和性别相关的变化可能会导致与年龄相关的运动功能下降和跌倒增加.
- 这项研究强调了将性视为衰老大脑研究中的生物变量的重要性.
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