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氧化介导的皮肤微血管功能在中年至老年人中在轻度SARS-CoV-2感染后没有改变:试点研究

Gabrielle A Dillon^1,2,3, S Tony Wolf¹, Auni C Williams¹

¹Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, State College, Pennsylvania, USA.

Physiological reports

|June 3, 2023

概括

与对照组相比,COVID-19后的成年人没有表现出氧化 (NO) 介导的皮肤血管扩张功能受损. 这表明,在COVID-19感染后,中年和老年人中,NO依赖的微血管功能保持不变.

科学领域:

生理学生理学生理学
心血管科学心血管科学
传染性疾病传染性疾病

背景情况:

COVID-19可以影响各种生理系统,包括血管功能.
氧化 (NO) 在调节血管扩张方面起着至关重要的作用.
需要对COVID-19对微血管功能的潜在长期影响进行调查.

研究的目的:

测试后COVID-19成年人与对照人群相比,皮肤NO介导血管扩张受损的假设.
评估COVID-19后成年人诊断后的时间,症状严重程度和微血管功能之间的关系.

主要方法:

横截面研究比较了7名COVID-19后 (PC) 和10名对照 (CON) 成年人 (平均年龄~67岁).
使用局部加热和用NG-nitro-L-arginine甲基的皮肤内微透析评估的皮肤NO依赖血管扩张.
红细胞流量用激光多普勒流量测量;皮肤血管导电率 (CVC) 计算.

主要成果:

在PC和CON组之间,NO依赖的血管扩张没有显著差异 (56%对60%CVCmax,p=0.77).
当地加热平原反应在各组之间也相似 (71%对81%CVCmax,p=0.77).
在PC组中,诊断后的时间和峰值症状严重程度与NO依赖的血管扩张无关.

结论:

患有COVID-19的中年和老年人没有表现出受损的NO依赖性皮肤血管扩张.
微血管功能,特别是NO介导的血管扩张,在COVID-19后的这个队列中似乎没有受到影响.
自诊断以来的时间和症状严重程度没有影响COVID-19后成年人的NO依赖血管扩张.

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