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基于石墨烯的场效应晶体管用于生物传感:电场的方向是什么?

Sabine Szunerits^1,2, Teresa Rodrigues^3,4, Rupali Bagale³

¹Univ. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France, UMR 8520 - IEMN, 59000, Lille, France. sabine.szunerits@univ-lille.fr.

Analytical and bioanalytical chemistry

|June 3, 2023

概括

石墨烯场效应晶体管 (gFET) 生物传感器在检测生物标志物方面表现有前途. 优化gFET设计和生物受体选择对于敏感和选择性的生物传感应用至关重要.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

二维 (2D) 材料,特别是石墨烯,在场效应晶体管 (FET) 配置中的生物传感应用中具有前景.
基于石墨烯的FET (gFET) 提供了通过调节电特性来检测生物受体-分析物结合事件的潜力.

研究的目的:

审查生物传感的gFET设计的最新进展.
突出优化gFET性能的策略,包括配置和表面连接体选择.
讨论在现实应用中实施gFET生物传感器的挑战和考虑因素.

主要方法:

审查关于gFET生物传感器设计的当前文献.
分析不同的gFET配置 (后门式,上门式,液门式).
评估生物感应器固定化策略及其对传感器性能的影响.

主要成果:

顶门式和液门式gFET配置正在越来越多地主导该领域.
gFET的设计和生物受体的选择显著影响传感器的灵敏度,选择性和可报告性.
已经证明使用gFET生物传感器成功检测核酸,蛋白质和病毒颗粒.

结论:

优化的gFET设计和适当的生物受体选择对于推进生物传感技术至关重要.
解决操作条件,灵敏度,选择性和经济可行性是广泛采用gFET生物传感器的关键.
对gFET设计和生物感应器策略的进一步研究将推动生物标志物检测方面的创新.

关键词:

生物受体是一种生物受体.场效应晶体管的领域效应晶体管.石墨烯是一种石墨烯.感应传感器感应传感器

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Field Effect Transistor

Field Effect Transistor

Field-effect transistors (FETs) are integral to electronic circuits and distinguished by their three-terminal setup: the gate, drain, and source. These transistors operate as unipolar devices, which utilize either electrons or holes as charge carriers, in contrast to bipolar transistors, which use both types of carriers. The primary function of the FET is to modulate the flow of these carriers from the source to the drain through a channel. The voltage difference between the gate and source...