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Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
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在 Tyr-82 探索共价键形成以抑制 Ral GTPase 激活

Alexander D Landgraf1, I-Ju Yeh1, Mona K Ghozayel1

  • 1Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

ChemMedChem
|June 3, 2023
PubMed
概括

研究人员开发了针对Ral GTPases的新型共价抑制剂,此前被认为是不可抗药的. 这些化合物阻断癌细胞的入侵,为新的胰腺癌治疗提供了潜力.

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