相关实验视频

Updated: Jul 28, 2025

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

晚期黑色素瘤中的微生物组:我们现在在哪里?

Dylan D Fortman¹, Drew Hurd², Diwakar Davar³

¹Division of General Internal Medicine, Department of Medicine, University of Pittsburgh Medical Center (UPMC) and University of Pittsburgh, Pittsburgh, PA, 15213, USA.

Current oncology reports

|June 3, 2023

概括

肠道微生物群对免疫检查点抑制剂 (ICI) 的黑色素瘤治疗结果产生影响. 通过饮食或益生菌调节肠道微生物群可以改善ICI反应并管理副作用.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
微生物学微生物学

背景情况:

免疫检查点抑制剂 (ICI) 已经彻底改变了黑色素瘤治疗.
肠道微生物组显著影响癌症治疗的疗效和毒性.
对肠道微生物组的调节是增强ICI治疗的有希望的策略.

研究的目的:

审查目前关于肠道微生物群在黑色素瘤患者对ICI反应中的作用的数据.
总结研究肠道微生物群干预黑色素瘤的临床试验的发现.

主要方法:

临床前和临床研究的文献综述.
分析数据,将肠道微生物群组成与ICI结果联系起来.
检查肠道微生物群特定的干预试验.

主要成果:

肠道微生物群的组成与黑色素瘤中的ICI反应和免疫相关不良事件 (irAEs) 有关.
诸如食纤维,益生菌和便微生物群移植 (FMT) 等干预措施显示出恢复或改善ICI疗效的潜力.
肠道微生物群是影响黑色素瘤ICI治疗的关键外部因素.

结论:

肠道微生物群调节是一种可行的策略,可以优化黑色素瘤的ICI治疗.
对微生物向干预措施的进一步研究可以改善患者的治疗结果并减少毒性.

关键词:

细胞毒性T淋巴细胞抗原-4 (CTLA-4)我们的肠道微生物组.免疫治疗是一种免疫疗法.黑色素瘤是一种黑色素瘤.编程死亡-1 (PD-1) 是指编程死亡的一种方式.

更多相关视频

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Published on: March 13, 2013

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...