在CKD中血管化:对其机制的新见解
Nannan Ding1, Yaodong Lv2, Hong Su1
1Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Journal of cellular physiology
|June 3, 2023
概括
慢性病 (CKD) 的血管化 (VC) 是一个活跃的过程,而不是被动的沉积. 表观遗传变化是关键驱动因素,为心血管事件提供潜在的治疗点.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管医学 心血管医学
- 分子生物学分子生物学
背景情况:
- 血管化 (VC) 是慢性病 (CKD) 的普遍并发症,显著增加心血管疾病发病率和死亡率.
- CKD中的VC是一种活跃的,细胞介导的过程,类似于骨形成,受过酸血,尿素毒素,氧化应激和炎症等因素的影响.
研究的目的:
- 审查CKD中VC的病理生理和分子机制.
- 突出表观遗传修饰在尿性VC中的关键作用.
- 探索对CKD相关心血管事件的潜在治疗策略.
主要方法:
- 文献综述侧重于了解CKD中VC机制的最新进展.
- 对调查表观遗传修饰 (DNA甲基化,基因组修饰,非编码RNAs) 在VC中的作用的研究进行分析.
- 综合当前关于风险因素和涉及尿性VC的分子途径的知识.
主要成果:
- 在CKD中,VC是一种活跃调节的,细胞介导的过程,与骨质生成有相似之处.
- 特定的CKD相关因素 (高酸血,尿素毒素,氧化应激,炎症) 导致VC的发展.
- 表观遗传异常,包括DNA甲基化,基因组修饰和非编码RNA,越来越被认为是VC的关键调节者.
结论:
- 了解CKD中VC的复杂机制对于开发有效疗法至关重要.
- 表观遗传修饰是未来治疗干预措施的有希望的目标,以减轻慢性病患者的心血管风险.
- 对VC表观遗传调节的进一步研究可能会导致针对CKD相关心血管并发症的新型治疗方法.
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