内镜特征有助于识别Cronkhite-Canada综合征中的结直肠多的组织病理模式
Qiu Shi Xu1, Yan You2, Shuang Liu1
1Department of Gastroenterology, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China.
Journal of digestive diseases
|June 3, 2023
概括
像大小,颜色和Kudo坑模式这样的内镜特征可以帮助区分Cronkhite-Canada综合征 (CCS) 的结直肠多. 这有助于在结肠镜检查期间识别非新发性聚体的腺瘤和低度发育不良 (LGD).
科学领域:
- 胃肠病学 胃肠病学
- 内镜成像系统的成像
- 在瘤学瘤学.
背景情况:
- 克朗希特-加拿大综合征 (CCS) 是一种罕见的,非遗传的哈马托马托多重症综合征.
- CCS显著增加了结直肠癌发生的风险.
- 在内镜检查过程中,从宏观上区分腺瘤和非新发性聚合体是具有挑战性的.
研究的目的:
- 为了研究CCS患者结直肠多的内镜特征.
- 为了将内镜检测结果与这些多重体的不同基因病理模式相关联.
主要方法:
- 对23名CCS患者的67个病变进行前性结肠镜检查.
- 活检或切除的聚体的组织病理学分析.
- 统计分析 (费舍尔的精确测试,多变量后勤分析) 以确定预测性内镜特征腺瘤和CCS与低度发育不良 (LGD).
主要成果:
- 组织病理学分析显示10.4%的腺瘤,29.9%的CCS-LGD和59.7%的非新发性息肉.
- 在聚体大小 (>20mm),颜色 (白色),形态 (形),Kudo坑模式 (类型IV和VI) 和腺瘤,CCS-LGD和非形聚体之间的内学活性之间观察到显著差异 (P <0.001).
- 腺瘤和CCS-LGD多体比非新发性多体更频繁地大,形,并表现出特定的Kudo坑模式.
结论:
- 内镜特征,包括多体大小,颜色,性,库多的坑格模式分类和内镜活动,对于区分CCS中的结直肠多体的基因病理模式是有价值的.
- 这些内镜检测结果可以帮助临床医生预测多组织学,指导管理决策,并可能改善早期发现CCS患者的瘤变化.
更多相关视频
15:49Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
Published on: October 16, 2013
31.9K
08:51Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
Published on: August 24, 2019
10.1K
相关概念视频
01:25Assessment of the Rectum and Anus
295
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
295
01:25Endoscopic Procedures II: Colonoscopy
145
The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
145
01:17Chronic Bowel Disorders: Introduction
493
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
493
01:26Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
115
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
115
01:27Histology of the Small Intestine
1.1K
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
1.1K
01:30Inflammatory Bowel Disease II: Crohn's Disease
306
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
306