相关实验视频

Updated: Jul 28, 2025

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

可膨胀核心技术平板电脑的样品制备方面的挑战:去除聚乙烯氧化物的方法和优化API回收的方法

Andrew Davidson¹, Elizabeth Morisseau¹, Alice Li²

¹Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA.

Journal of pharmaceutical and biomedical analysis

|June 3, 2023

概括

这项研究开发了一种方法,从可膨胀核心技术 (SCT) 平板的分析样本中去除聚乙烯氧化物 (PEO). 这优化了活性药物成分 (API) 的回收,以便进行精确的测试.

科学领域:

制药科学制药科学
分析化学分析化学
药物输送系统药物输送系统

背景情况:

可膨胀核心技术 (SCT) 平板是专为控制药物释放而设计的固体口服剂型.
这些药片由一个活性层和一个膨胀层组成,两者都含有大量的聚乙烯氧化物 (PEO).
在SCT片中精确量化活性药物成分 (API) 需要有效地从分析试验溶液中去除PEO.

研究的目的:

开发一种高效的工艺,从可膨胀核心技术 (SCT) 片的分析溶液中去除聚乙烯氧化物 (PEO).
通过利用其独特的物理化学性质,优化活性药物成分 (API) 的回收.
建立一个可靠的分析方法来量化复杂的SCT平板电脑矩阵中的API.

主要方法:

使用液态色谱 (LC) 与蒸发光散射探测器 (ELSD) 结合,进行了PEO的量化.
研究了固态提取 (SPE) 和液态提取 (LLE) 技术,以消除PEO.
使用API的物理化学特性来指导优化样品清理程序.

主要成果:

通过LC-ELSD分析,可以了解PEO去除效率.
评估了提取技术,以确定PEO消除的最佳条件.
提出了一项工作流程,以有效地开发SCT片的分析方法,重点是样本准备.

结论:

为分析可吞核心技术 (SCT) 平板电脑开发了一种有效的样本清理策略.
拟议的工作流促进了优化的API恢复和准确的量化.
这项研究有助于控制释放配方的可靠分析特征.

关键词:

蒸发式光散射是一种蒸发式光散射.聚乙烯氧化物聚乙烯氧化物在SCT上,我们可以看到SCT.可膨胀的核心技术技术

更多相关视频

Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface

Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface

Published on: August 11, 2017

High Throughput Single-cell and Multiple-cell Micro-encapsulation

High Throughput Single-cell and Multiple-cell Micro-encapsulation

Published on: June 15, 2012

相关概念视频

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...