患有IPF或肉类瘤的患者的呼吸道和非呼吸道症状和对照
Ada E M Bloem1, Sarah Houben-Wilke2, Rémy L M Mostard3
1University of Applied Sciences Utrecht, Institute of Movement Studies, Faculty of Health Care, Utrecht, the Netherlands; ILD Centre of Excellence, Department of Pulmonology, St. Antonius Hospital, Nieuwegein, the Netherlands.
Heart & lung : the journal of critical care
|June 3, 2023
概括
患有异常性肺纤维化 (IPF) 或类麻疹患者的呼吸和非呼吸症状明显比健康人群多. 这凸显了需要更多的意识和研究来管理这些条件下的症状负担.
科学领域:
- 肺部病理学 肺部病理学
- 临床医学 临床医学
- 患者报告的结果
背景情况:
- 异形性肺纤维化 (IPF) 和沙尔科毒症患者经常患有呼吸障碍和咳.
- 非呼吸系统症状,如疲劳和肌肉衰弱也很常见,但研究较少.
- 这些呼吸道疾病与健康个体之间的比较症状负担尚未得到充分理解.
研究的目的:
- 量化和比较患者的呼吸和非呼吸症状的负担与IPF和肉类瘤.
- 为了比较这些患者群体的症状负担与没有明显呼吸道疾病的对照组.
主要方法:
- 一项横截面研究涉及59名IPF患者,60名肉类发病患者和118名年龄和性别匹配的对照.
- 用视觉模拟尺度对14种不同的症状进行症状严重程度评估.
- 收集了人口统计数据和螺旋计值 (FVC,FEV1).
主要成果:
- 与对照组相比,IPF患者报告了11种症状的严重程度明显更高,特别是呼吸障碍,咳,疲劳,肌肉衰弱和失眠.
- 与对照组相比,在所有14种评估的症状中,沙丘病患者报告的严重程度显著更高.
- 沙尔科发病中最大差异的关键症状包括呼吸不全,疲劳,咳,肌肉疲软,失眠,疼痛和尿路症状.
结论:
- 与没有肺部疾病的个人相比,IPF和沙尔科毒症都与呼吸道和非呼吸道症状的负担显著增加有关.
- 提高临床对IPF和沙尔科病综合性症状负担的认识至关重要.
- 需要进一步的研究来阐明这些症状背后的机制,并制定有针对性的干预措施.
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