患有的儿童死亡率:使用临床实践研究数据链接的队列研究
Christian Schnier1, Richard F Chin2
1Muir Maxwell Epilepsy Centre, Centre for Clinical Brain Sciences, Edinburgh.
Seizure
|June 3, 2023
概括
患有的儿童 (CWE) 面临着明显更高的死亡风险,与没有的儿童 (CWOE) 相比,死亡风险增加了50倍. 在CWE中,大多数死亡不是与有关的,非自然死亡并不常见.
科学领域:
- 儿科神经学 儿科神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 是一种常见的儿童神经系统疾病.
- 了解 (CWE) 儿童的死亡模式对于改善护理和治疗结果至关重要.
- 之前的研究还没有完全阐明这个人群中特定的死亡风险和死亡原因.
研究的目的:
- 估计英国患有的儿童 (CWE) 与没有的儿童 (CWOE) 的死亡率 (MR).
- 确定和描述CWE中死亡的原因.
- 分析伴随疾病对CWE死亡率的贡献.
主要方法:
- 一个回顾性队列研究,使用临床实践研究Datalink Gold (1998-2017) 的链接数据.
- 通过使用验证的代码来确定的诊断.
- 考克斯比例危险分析用于评估死亡风险.
主要成果:
- 这项研究包括1,191,304名儿童,其中9,665名 (0.8%) 被诊断为.
- 与没有 (CWOE) 的儿童相比,患有 (CWE) 的儿童的全因死亡率 (MRR 50.9) 显著增加.
- 在CWE的死亡中,24%与有关,非自然死亡不常见 (2%).
结论:
- 与同龄人相比,患有的儿童的死亡风险明显增加.
- 大多数患有的儿童的死亡并不是直接归因于发作.
- 对伴随性疾病和与无关的死亡原因进行进一步的研究是有必要的,以减少CWE中的死亡率.
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