在非酒精性脂肪肝疾病中,有氧运动训练后肺血管运动调节器的变化
Jinkyung Cho1, Bruce D Johnson1, Kymberly D Watt2
1Department of Cardiovascular Disease, Mayo Clinic, Rochester, MN, USA.
Respiratory physiology & neurobiology
|June 3, 2023
概括
运动训练有利于非酒精性脂肪肝疾病 (NAFLD) 的肺血管系统. 它有助于调节诸如诱导性氧化合成酶 (iNOS) 和内甲素-1 (ET-1) 等关键介质,这些介质在NAFLD中发生变化.
科学领域:
- 心血管生理学心血管生理学
- 肝病学 肝病学是一种肝病学.
- 运动科学 运动科学
背景情况:
- 非酒精性脂肪肝 (NAFLD) 与心血管并发症有关.
- 肺血管运动度对于血管健康至关重要.
- 运动对NAFLD肺中介体的影响尚未完全理解.
研究的目的:
- 在高脂肪高碳水化合物 (HFHC) 饮食诱导的NAFLD模型中研究运动训练对肺血管运动媒介和受体的影响.
- 评估内皮氧化合成酶 (eNOS),可诱导的NOS (iNOS),内皮林-1 (ET-1) 和其受体 (ETA,ETB) 的变化.
主要方法:
- 使用HFHC饮食模型诱导动物对象的NAFLD.
- 管理炼训练方案以评估其影响.
- 测量了NNOS,NNOS,ET-1,ETA和ETB的肺部水平.
主要成果:
- NAFLD显著增加了iNOS,ET-1和ETA的表达.
- 运动训练有效地减轻了 iNOS,ET-1和ETA水平的升高.
- 在NAFLD模型中,运动没有显著改变ETB或eNOS水平.
结论:
- 运动训练在NAFLD中对肺血管有有益影响.
- 运动有助于使关键的血管运动介质正常化,这些介质与NAFLD相关的血管功能障碍有关.
- 通过运动准这些途径可能为NAFLD并发症提供治疗潜力.
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