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状腺癌国际分级系统的独立验证:一个单一机构的经验

Daniel J Lubin¹, David Blake Behrman², Subir Goyal³

¹Department of Pathology, Emory University Hospital Midtown, Atlanta, Georgia; Winship Cancer Institute, Emory University Hospital, Atlanta, Georgia.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

|June 3, 2023

概括

国际MTC分级系统 (IMTCGS) 能够有效预测甲状腺髓癌 (MTC) 的结果. 该系统包含了亡,Ki67PI和线粒细胞计数,已被验证用于例行病理实践,以改善MTC预后预测.

科学领域:

在瘤学瘤学.
病理学病理学病理学

背景情况:

甲状腺髓性癌 (MTC) 是一种罕见但致命的甲状腺恶性瘤.
预测MTC临床行为对于患者的治疗结果至关重要.
国际MTC分级系统 (IMTCGS) 结合了关键的预后因素.

研究的目的:

在一个不同的MTC队列中独立验证IMTCGS.
评估IMTCGS预测临床结果的能力,包括生存率.
评估单个IMTCGS组件的预后意义.

主要方法:

追溯分析87例MTC病例 (30种生殖系,57种零星).
组织学审查和Ki67免疫染对线粒细胞计数和Ki67增殖指数 (Ki67PI).
应用IMTCGS (死,Ki67PI,线粒细胞计数) 和Cox回归用于生存分析.

主要成果:

18.4%的MTC被归类为IMTCGS高等级.
IMTCGS等级显著预测了整体存活率,无病存活率,疾病特异性存活率和远程无转移存活率.
在多变量分析中,瘤亡与生存结果的关联最强.

结论:

IMTCGS是MTC的有效和独立的预后工具.
将IMTCGS纳入常规病理学实践可以帮助预测MTC预后.
需要进一步的研究,以将MTC分级纳入治疗方案.

关键词:

国际分级系统国际分级系统骨髓甲状腺癌,甲状腺癌.甲状腺是什么?甲状腺是什么?验证验证的时间

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