最好的 (但经常被遗忘) 实践:用于常用的试验设计的高效样本大小
Math J J M Candel1, Gerard J P van Breukelen2
1Department of Methodology and Statistics, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, Netherlands.
The American journal of clinical nutrition
|June 3, 2023
概括
研究人员提出了研究设计,最大限度地提高统计能力,同时最大限度地减少资源使用. 这些最佳和最大设计确保随机试验的可靠结果,即使数据和预算有限.
科学领域:
- 生物统计学 生物统计学
- 临床试验设计 临床试验设计
- 研究方法研究方法研究方法学
背景情况:
- 高的统计能力对于研究质量和可重复性至关重要.
- 资源限制需要高效的研究设计.
- 在随机试验中,对受试者和资源的最佳分配是关键.
研究的目的:
- 在随机试验中提出研究设计,以尽量减少对象或预算,以达到所需的功率水平.
- 引入最大限度设计,保证跨参数范围的功率,并最大限度地降低成本.
- 专注于平行,交叉和嵌套试验设计的连续结果.
主要方法:
- 开发最优的设计,用于主题分配和资源使用.
- 实施最大限度设计,以考虑未知的参数,如结果差异.
- 将这些设计应用于2组并行,AB/BA交叉,集群随机和多中心试验.
主要成果:
- 用于计算最佳和最大设计的样本大小的证明方法.
- 插图计算与营养研究示例.
- 讨论了用于样本大小计算的计算机程序和各种结果的最佳设计.
结论:
- 优化和最大化设计提高了随机临床试验的效率和可靠性.
- 这些方法对于资源意识的研究至关重要,特别是具有持续结果的研究.
- 提出的方法和工具有助于研究人员有效地实现所需的统计能力.
关键词:
集群随机化试验是指集群随机化试验.跨界车的设计设计.有效的试验试验试验.马克西明设计设计多中心试验试验.最佳设计的最佳设计.平行组设计平行组设计.权力,权力,权力,权力.反复采取措施反复采取措施.样本大小计算 样本大小计算更多相关视频
10:26Problem-Solving Before Instruction PS-I: A Protocol for Assessment and Intervention in Students with Different Abilities
Published on: September 11, 2021
4.0K
08:36Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
Published on: April 19, 2024
612
相关概念视频
Sample Size Calculation
3.6K
Knowledge of the sample size is the first requirement to conduct random sampling or an experiment. The sample size is the total number of units, observations, or groups (in some cases) used to get the data to estimate a population parameter. As the name suggests, the sample size is that of the sample drawn from the population and differs from the population size.
The sample size for the given experiment or sampling effort is fundamental to any study design. Sample size decides the number of...
The sample size for the given experiment or sampling effort is fundamental to any study design. Sample size decides the number of...
3.6K
Testing a Claim about Population Proportion
3.4K
A complete procedure for testing a claim about a population proportion is provided here.
There are two methods of testing a claim about a population proportion: (1) Using the sample proportion from the data where a binomial distribution is approximated to the normal distribution and (2) Using the binomial probabilities calculated from the data.
The first method uses normal distribution as an approximation to the binomial distribution. The requirements are as follows: sample size is large...
There are two methods of testing a claim about a population proportion: (1) Using the sample proportion from the data where a binomial distribution is approximated to the normal distribution and (2) Using the binomial probabilities calculated from the data.
The first method uses normal distribution as an approximation to the binomial distribution. The requirements are as follows: sample size is large...
3.4K
One-Way ANOVA: Equal Sample Sizes
3.3K
One-Way ANOVA can be performed on three or more samples with equal or unequal sample sizes. When one-way ANOVA is performed on two datasets with samples of equal sizes, it can be easily observed that the computed F statistic is highly sensitive to the sample mean.
Different sample means can result in different values for the variance estimate: variance between samples. This is because the variance between samples is calculated as the product of the sample size and the variance between the...
Different sample means can result in different values for the variance estimate: variance between samples. This is because the variance between samples is calculated as the product of the sample size and the variance between the...
3.3K
Group Design
9.0K
The most basic experimental design involves two groups: the experimental group and the control group. The two groups are designed to be the same except for one difference— experimental manipulation. The experimental group gets the experimental manipulation—that is, the treatment or variable being tested—and the control group does not. Since experimental manipulation is the only difference between the experimental and control groups, we can be sure that any differences between...
9.0K
One-Way ANOVA: Unequal Sample Sizes
5.8K
One-way ANOVA can be performed on three or more samples of unequal sizes. However, calculations get complicated when sample sizes are not always the same. So, while performing ANOVA with unequal samples size, the following equation is used:
5.8K
Sampling Plans
219
Sampling is a crucial step in analytical chemistry, allowing researchers to collect representative data from a large population. Common sampling methods include random, judgmental, systematic, stratified, and cluster sampling.
Random sampling is a method where each member of the population has an equal chance of being selected for the sample. It involves selecting individuals randomly, often using random number generators or lottery-type methods. For example, when analyzing the properties of a...
Random sampling is a method where each member of the population has an equal chance of being selected for the sample. It involves selecting individuals randomly, often using random number generators or lottery-type methods. For example, when analyzing the properties of a...
219
