5-甲用于治疗声痕的治疗
Bailey Balouch1, Parastou Azadeh Ranjbar1, Alex Barna1
1Drexel University College of Medicine, Philadelphia, Pennsylvania.
概括
与甲相比,5-fluorouracil (5-FU) 注射显著改善了声 (VF) 振动功能和粘膜波在患有VF痕的患者. 以往德克萨米他治疗失败预测了对5-FU的积极反应.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 再生医学是一种再生医学.
- 声音科学 声音科学
背景情况:
- 声 (VF) 痕损害了振动功能,往往治疗选择有限.
- 5-甲 (5-FU),一种抗代谢物,在痕治疗和VF痕动物模型中表现有前途.
- 目前用于VF痕的治疗方法具有可变的疗效,需要新的治疗方法.
研究的目的:
- 为了评估5-甲 (5-FU) 注射在改善声 (VF) 振动功能的有效性,在患有VF痕的患者.
- 为了比较5-FU注射与德克萨米他注射作为对照治疗的结果.
- 评估痕大小的变化,喉关闭,VF硬度和粘膜波浪特征.
主要方法:
- 成年患有VF痕的患者接受了一系列三次5-FU注射或甲注射.
- 测量结果包括改善率,痕大小,关闭,静脉硬度和粘膜波的数字图像分析.
- 在5-FU和甲治疗组之间进行了比较分析.
主要成果:
- 接受5-FU治疗的61.22%的患者表现出改善,而使用德克萨米他治疗的51.06%患者表现出改善.
- 与德甲组相比,5-FU组在术后的粘膜波中表现出显著更大的改善.
- 那些以前未能接受德克萨梅他治疗的患者在5 - FU注射后的改善率为84.21%.
结论:
- 一系列三次内溶性5-FU注射比德甲更有效地改善VF痕患者的粘膜波.
- 德克萨米他注射失败的病史预测了对5-FU治疗的良好反应.
- 需要进一步的研究来验证这些发现,并优化5-FU治疗方案的VF痕.
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