性饮食大大重塑了人类的新陈代谢
David Effinger1, Simon Hirschberger1, Polina Yoncheva2
1Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilian-University Munich (LMU), Munich, Germany; Department of Anaesthesiology, Research Unit Molecular Medicine, University Hospital, LMU Munich, Munich, Germany.
Clinical nutrition (Edinburgh, Scotland)
|June 3, 2023
概括
性饮食 (KD) 迅速改变人类的新陈代谢,改善胰岛素和甘油三水平,同时增加抗炎化合物. 这种安全的干预措施显示出作为免疫调节的预防和治疗工具的希望.
科学领域:
- 免疫代谢过程中的免疫代谢.
- 营养科学 营养科学
- 代谢学 代谢学 代谢学
背景情况:
- 西方饮食 (WD) 促进与非传染性疾病有关的慢性炎症.
- 性饮食 (KD) 正在成为WD诱导的元炎症的免疫调节对策.
- 以前的研究仅将KD的好处归因于体,而忽视了更广泛的代谢转变.
研究的目的:
- 调查KD引起的人类代谢组的综合性变化.
- 确定有助于KD对免疫力的积极影响的特定代谢物.
- 识别与KD相关的潜在健康风险.
主要方法:
- 对40名健康志愿者进行前性营养干预研究.
- 三周的前期KD,然后进行非向的血清代谢分析.
- 分析尿液中的托芬通路.
主要成果:
- 凯迪显著降低了胰岛素和c-水平,但没有影响血糖.
- 代谢分析显示,发生了转向线粒体脂肪酸氧化过程的转变,其中自由脂肪酸和甲酸的含量增加.
- 观察到抗炎性脂肪酸的增加和氨基酸配置的改变,以及托通路的变化.
结论:
- 一个KD在三周内深刻地改变了人类的新陈代谢.
- 凯迪改善了代谢标记,增强了抗炎途径,并支持线粒体功能.
- 没有发现代谢风险因素,这表明KD是一种安全的免疫代谢工具.
相关概念视频
Overview of Lipid Metabolism
1.9K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.9K
Metabolic States of the Body: Fasting and Starvation
1.6K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
1.6K
Overview of Metabolism
31.4K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
31.4K
Metabolic States of the Body: The Postabsorptive State
385
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
385
Regulation of Metabolism
9.5K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.5K
Introduction to Metabolism
136
Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
136


