前列腺特异性抗原水平与COVID-19感染和接种疫苗的关联
Michael Frumer1, Shachar Moshe Aharony1, Ohad Shoshany1
1Department of Urology, Rabin Medical Center, Petah Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
感染SARS-CoV-2和接种疫苗会略微增加前列腺特异性抗原 (PSA) 水平. 第三剂COVID-19疫苗显示出更显著的影响,但需要进一步调查临床意义.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 前列腺特异性抗原 (PSA) 查对于前列腺癌检测至关重要.
- 感染SARS-CoV-2和接种疫苗对PSA水平的影响尚不清楚.
研究的目的:
- 在接受前列腺癌查的男性中,调查SARS-CoV-2感染,疫苗接种和血清PSA总水平之间的关联.
主要方法:
- 对23,019名年龄在50-75岁之间的男性进行了回顾性分析,并进行了两次PSA测试.
- 在接种疫苗/感染个体和未接种疫苗/未感染对照人群之间比较PSA变化.
- 亚组分析,以评估过去时间的影响.
主要成果:
- 患有SARS-CoV-2事件的个体表现出更高的PSA升高 (0.04vs0.02 ng/dL).
- 对PSA升高≥1 ng/dL的相对风险为1.22.
- 接种疫苗与PSA增加有关,第三剂量显示出更突出的效果 (0.09 ng/dL增加).
结论:
- 感染SARS-CoV-2和接种疫苗与轻微的PSA增加有关.
- 这种PSA升高的临床意义需要进一步研究.
- 应调查PSA显著增加,而不是仅仅归因于COVID-19事件.
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