Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Peripheral Blood T-Cell Receptor Repertoire and Host Immune Background in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy.

Acta medica Okayama·2026

Same author

Abdominal Paraaortic Lymphadenopathy With Progressive Transformation of Germinal Centers.

Pediatrics international : official journal of the Japan Pediatric Society·2026

Same author

Adult T-cell leukaemia/lymphoma with different histological features in a single lymph node.

Journal of clinical and experimental hematopathology : JCEH·2026

Same author

Fibrin-associated large B-cell lymphoma arising in benign gynecologic tumors: insights into disease spectrum expansion and pathophysiology.

Virchows Archiv : an international journal of pathology·2026

Same author

[Successful treatment with brentuximab vedotin for MYC positive syncytial variant nodular sclerosis Hodgkin lymphoma].

[Rinsho ketsueki] The Japanese journal of clinical hematology·2026

Same author

A case of primary testicular adult T-cell leukemia/lymphoma (ATLL): ATLL of immune privileged site.

Journal of clinical and experimental hematopathology : JCEH·2025

Search research articles

相关实验视频

Updated: Jul 28, 2025

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

在CD4的数字空间配置文件.

Mai Takeuchi¹, Hiroaki Miyoshi¹, Yuichiro Semba²

¹Department of Pathology, Kurume University School of Medicine, Kurume City, Fukuoka, Japan.

Virchows Archiv : an international journal of pathology

|June 3, 2023

概括

此摘要是机器生成的。

经典的霍奇金淋巴瘤 (CHL) 具有与瘤细胞相互作用的CD4+T细胞列. 这些罗塞特显示出更高的免疫检查点分子表达,为CHL瘤微环境提供了新的见解.

关键词:

CD4+ T 细胞的红.经典的霍奇金淋巴瘤是一种典型的霍奇金淋巴瘤.数字空间概况设计的数字空间概况.霍奇金 - 里德 - 斯特恩伯格细胞瘤微环境是一个微环境.

更多相关视频

CD4+ T-Lymphocyte Capture Using a Disposable Microfluidic Chip for HIV

CD4+ T-Lymphocyte Capture Using a Disposable Microfluidic Chip for HIV

Published on: October 1, 2007

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry

Published on: January 7, 2019

相关实验视频

Last Updated: Jul 28, 2025

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

CD4+ T-Lymphocyte Capture Using a Disposable Microfluidic Chip for HIV

CD4+ T-Lymphocyte Capture Using a Disposable Microfluidic Chip for HIV

Published on: October 1, 2007

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry

Published on: January 7, 2019

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
病理学病理学病理学

背景情况:

经典霍奇金淋巴瘤 (CHL) 的特点是罕见的恶性霍奇金-里德-斯特恩伯格 (HRS) 细胞在丰富的炎症透中.
CD4+ T 细胞在 HRS 细胞周围形成鲜明的红,这表明它们在瘤微环境 (TME) 中起着至关重要的作用.

研究的目的:

为了研究CHL中HRS细胞周围的CD4+T细胞列表的基因表达特征.
在CHL TME中阐明HRS细胞和CD4+ T细胞之间的功能相互作用.

主要方法:

采用数字空间分析来比较CD4+ T细胞罗列和其他CD4+ T细胞之间的基因表达.
免疫组织化学被用来验证关键免疫检查点分子的表达.

主要成果:

与其他CD4+T细胞相比,CD4+T细胞罗塞特表现出显著更高的免疫检查点分子表达,包括OX40,编程细胞死亡-1 (PD-1) 和细胞毒性T淋巴细胞相关蛋白4 (CTLA-4).
免疫组织化学分析证实了这些CD4+T细胞列表中PD-1,CTLA-4和OX40的可变表达.

结论:

这项研究引入了一种新的病理方法来分析CHL TME.
这些发现为CD4+ T细胞在CHL中与HRS细胞相邻的特定作用和免疫状态提供了更深入的见解.