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爪的DNA甲基化时钟揭示了表观遗传衰老的进化保护

Joseph A Zoller¹, Eleftheria Parasyraki², Ake T Lu^3,4

¹Department of Biostatistics, School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.

|June 3, 2023

概括

通过DNA甲基化测量表观遗传衰老,在青和哺乳动物之间保持. 在Xenopus青中的这一发现突出了参与衰老的保存的神经基因,这表明青是衰老研究的模型.

科学领域:

进行比较的基因组学.
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
进化生物学是进化的生物学.

背景情况:

基于DNA甲基化的表观遗传衰老是一种保存的生物过程.
了解哺乳动物以外的表观遗传衰老的进化保护对于衰老研究至关重要.

研究的目的:

研究各种物种中基于DNA甲基化的表观遗传衰老的保护.
开发和验证适用于人类和青的表观遗传钟.
确定与Xenopus. epigenetic衰老相关的保存基因.

主要方法:

来自非洲爪 (Xenopus laevis) 和西方爪 (Xenopus tropicalis) 的DNA甲基化数据的生成.
双物种表观遗传钟的发展 (人类爪的青钟).
在特定基因内识别保存的与年龄相关的CpG位点.

主要成果:

表观遗传衰老过程在哺乳动物以外的进化过程中得到了保存,正如双物种钟所证明的那样.
在神经发育基因 (例如,uncx,tfap2d,nr4a2) 中发现了高度保守的,与年龄相关的CpG.
这些基因与年龄相关的疾病有关,这表明神经过程与衰老之间存在联系.

结论:

青和哺乳动物之间保留了表观遗传衰老的特征.
与Xenopus的表观遗传衰老相关的保存基因主要与神经过程有关.
克塞诺普斯物种代表了一个有价值的模型生物来研究衰老的机制.

关键词:

衰老的生物标志物.有爪的青基因表观时钟是什么?进化进化进化进化进化进化进化甲基化甲基化甲基化

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