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非编码RNA作为乳腺癌预后,诊断和临床实用性的生物标志物的流行率

Rafat Ali¹, Sorforaj A Laskar¹, Nida Jamil Khan²

¹Department of Biosciences, Jamia Millia Islamia University, New Delhi, India.

Functional & integrative genomics

|June 3, 2023

概括

非编码RNAs (ncRNAs),包括microRNAs (miRNAs) 和长非编码RNAs (lncRNAs),在基因调节和生物过程中起着至关重要的作用. 这项研究探讨了它们在乳腺癌发展中的功能,以及它们作为诊断和治疗点的潜力.

科学领域:

分子生物学分子生物学
遗传学遗传学是一个
在瘤学瘤学.

背景情况:

非编码RNAs (ncRNAs) 构成了哺乳动物转录组的重要组成部分,调节基因表达和生物过程.
特定的ncRNA如microRNAs (miRNAs),piwi相互作用RNAs (piRNAs) 和长非编码RNAs (lncRNAs) 都与细胞功能和疾病有关.
对ncRNAs,特别是lncRNAs的失调与包括乳腺癌在内的各种癌症的发展有关.

研究的目的:

阐明小ncRNAs (sncRNAs),包括miRNAs和piRNAs和lncRNAs在乳腺癌发病和进展中的作用.
审查ncRNAs在关键发育过程中的参与,例如乳腺发育.
讨论ncRNAs在开发乳腺癌新型诊断,预后和治疗策略方面的潜力.

主要方法:

文献综述和现有关于乳腺癌中ncRNA功能研究的综合研究.
对研究研究miRNAs,piRNAs和lncRNAs在癌症中的调节机制的分析.
检查将ncRNA表达模式与乳腺癌发展和进展联系起来的数据.

主要成果:

ncRNAs,包括miRNAs和lncRNAs,是正常发育中的关键调节者,并且在乳腺癌中经常失调.
特定的ncRNAs影响与癌症相关的关键细胞过程,例如干细胞调节和发育途径.
对ncRNAs的异常表达与乳腺癌的瘤发病,进展和转移有关.

结论:

通过多种不同的调节机制,ncRNAs显著促进乳腺癌的发病.
了解ncRNA功能,可以了解乳腺癌的复杂生物学.
基于ncRNA的方法有望在乳腺癌诊断,预后和治疗方面取得未来进展.

关键词:

乳腺癌:ncRNAs 的研究在PIWI-RNAs中.在 lncRNAs 中.这就是miRNAs.

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