奖励反应与情感和酒精问题的同时和未来的关联:与ADHD相关的差异性脆弱性
Alexandra Rádosi1,2, Kristóf Ágrez1, Bea Pászthy3
1Clinical and Developmental Neuropsychology Research Group, Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Budapest, Hungary.
Journal of youth and adolescence
|June 3, 2023
概括
对奖励的神经反应对青少年心理健康的影响不同,基于注意力缺陷/多动症 (ADHD) 风险. 处于危险的年轻人中,大脑反应的增加与抑郁症的减少,但更多的酒精使用有关,与没有ADHD风险的同龄人不同.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 注意缺陷/多动障碍 (ADHD) 是一种复杂的疾病,表现不同.
- 了解中介表型,如神经反应,对于ADHD的精确精神病学至关重要.
- 奖励系统活动与ADHD相关结果之间的关系需要进一步研究.
研究的目的:
- 为了研究神经对奖励成就的反应如何在有风险的青少年与没有风险的青少年之间有所不同.
- 检查与奖励相关的神经活动与情感,外化,内化和酒精使用问题的并发和潜在关联.
- 为了确定ADHD状态是否调节这些关联.
主要方法:
- 功能磁共振成像 (fMRI) 测量了129名青少年的奖励获得与损失的神经反应.
- 参与者包括50名患有ADHD (亚临床) 风险的青少年和79名没有风险的青少年.
- 在18个月的时间里,同时和前性地评估了大脑活动 (上额,前) 和心理健康结果之间的关联.
主要成果:
- 在有风险的年轻人中,更高的上额回应与较低的抑郁问题有关,这种联系在非有风险的年轻人中不存在.
- 在有风险的年轻人中,更大的面反应预测了危险酒精使用的增加,而在非有风险的年轻人中,它预测了较低的酒精使用.
- 这些发现表明,神经对奖励的反应性差异预测了基于ADHD风险状况的情绪和物质使用问题.
结论:
- 对奖励成就的神经反应是一种跨诊断的表型,差异性地赋予了青少年抑郁和酒精问题的脆弱性.
- 较高的额头回环活动与抑郁问题相关,酒精问题的门活动,方向根据ADHD风险调节.
- 这些见解支持开发针对ADHD的有针对性的干预措施,通过识别潜在的特定结果的独特神经机制.
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