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治疗前系统性炎症评分是食道癌老年患者的预后预测指标:一项病例对照研究
Chunyue Huang1, Mengyao Wang1, Liwen Chen2
1Department of Radiation Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China.
新的系统性炎症评分 (SIS) 有效预测了接受放射治疗的老年食道状细胞癌患者的结果. 较低的SIS表明更好的生存率,优于其他标志物和指导治疗选择.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 生物标志物 生物标志物
背景情况:
- 系统性炎症评分 (SIS) 由血清白蛋白 (Alb) 和淋巴细胞与单细胞比率 (LMR) 衍生,是一种新的预后工具.
- 它作为术后预后标记物的实用性已被确立为某些癌症.
- 它在接受放射治疗的老年食道状细胞癌 (ESCC) 患者的预测价值尚不清楚.
研究的目的:
- 评估SIS在接受放射治疗的老年ESCC患者的预后价值.
- 将SIS的预测准确度与其他炎症标志物进行比较.
- 评估ESCC患者不同SIS水平的最佳治疗策略.
主要方法:
- 对166名老年ESCC患者的回顾性分析,这些患者接受了放射治疗 (有或没有化疗).
- 根据Alb和LMR水平,患者被分类为SIS组 (0,1,2).
- 使用卡普兰-梅尔的生存分析,单变量/多变量分析和时间依赖的ROC曲线.
主要成果:
- 较低的SIS与更好的整体存活率 (OS) 和无进展存活率 (PFS) 有显著的关联.
- 与Alb,LMR,NLR,PLR和SII相比,SIS显示了OS的更高的预测准确性.
- 对于SIS高的患者,同时使用单一药物 (CCRT-1) 进行化学放射治疗,与CCRT-2 (15%) 相比,显示3年后的OS率 (42%) 改善.
结论:
- 对于接受放射治疗或化学放射治疗的老年ESCC患者来说,SIS是一种有价值的预后标志物.
- SIS为OS提供了比连续Alb更好的预测能力,并且可以在不同的治疗方案中对预后进行分层.
- 对于SIS高ESCC患者来说,CCRT-1可能是最佳的治疗方法.
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