ABPEPserver:一个用于记录和分析替代品的网络应用程序
Abhijeet Pataskar1, Jasmine Montenegro Navarro2, Reuven Agami3,4
1Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, the Netherlands. a.pataskar@nki.nl.
我们介绍了ABPEPserver,这是一个新的数据库,用于对人类癌症中的替代性进行分类. 本资源有助于通过分析异常蛋白质表达及其与基因签名的关联来识别潜在的免疫疗法标.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物信息学是一种生物信息学.
- 蛋白质组学是指蛋白质组学.
背景情况:
- 癌症免疫疗法依赖于识别细胞表面抗原以引起T细胞反应.
- 来自遗传改变的新抗原是经典的目标,但正在出现一种新的类别,即由异常蛋白质翻译产生的替代物.
- 人类癌症中替代体表达,特异性和基因关联的目录目前有限.
研究的目的:
- 介绍ABPEPserver,一个在线数据库和分析平台,用于可视化人类癌症中的替代体表达.
- 为分析替代的基因关联特征提供工具.
- 为了促进瘤和正常组织之间的替代剂丰富的比较,并确定免疫疗法候选人.
主要方法:
- 在R Shiny平台上开发了ABPEP服务器.
- 整合了来自八种瘤类型的CPTAC数据库的大规模瘤蛋白质学数据.
- 实现了基因关联签名,组织比较和候选识别的分析功能.
主要成果:
- ABPEPserver提供了八种人类癌症类型的替代性的全面目录.
- 该平台可以分析替代性基因关联及其在瘤与正常组织中的差异表达.
- 已确定候选人 替代性酸用于潜在的免疫疗法设计.
结论:
- ABPEPserver是探索人类癌症中异常蛋白质生产的宝贵资源.
- 该平台增强了用于免疫疗法开发的新型癌症抗原的发现.
- 在线可以访问ABPEPserver,其代码可在GNU通用公共许可证下使用.
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